一、履历

王珍，女，汉族，博士，硕士生导师，讲师。2012年毕业于河北大学生物技术专业，获学士学位；2017年毕业于复旦大学生物化学与分子生物学专业，获理学博士位。2019年美国明尼苏达大学访问学者。复旦大学优秀毕业生获得者、河北省糖尿病基础医学研究重点实验室（筹）外聘研究员。

二、研究方向

目前主要从事对活性成分对代谢性相关疾病的作用及机制，基于体内体外实验，结合高通量测序和代谢组学，解析成分作用及干预策略。

三、主要科研成果

作为主研人参加国家、市课题2项，作为主持人主持省自然科学基金、教育厅、市科技局等项目课题4项。

四、代表性论文

1.Zhen Wang, Peng Liu, Xin Zhou, Tianxiang Wang, Xu Feng, Yi-Ping Sun, Yue Xiong, Hai-Xin Yuan and Kun-Liang Guan. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Research. 2017 May 1;77(9):2413-2423.

2.Zhen Wang, Li Sun, Shuang Liang, Zan-chao Liu , Zeng-yi Zhao , Jie Yang , Defeng Wang , Da-Qing Yang. GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCb-PKC and Rho/ROCK-LIMK-Cofilin pathway. Biochem Biophys Res Commun. 2019 Aug 27;516(3):976-982.

3. Hai-Xin Yuan,Zhen Wang, Fa-Xing Yu, Fulong Li, Ryan C. Russell, Jenna L. Jewell, Kun-Liang Guan. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes and Development. 2015 Nov 15; 29(22):2362-76.

4. Xin Zhou†,Zhen Wang†，Wei Huang, Qun-ying Lei. G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):10-5.

5. Wei Huang†,Zhen Wang†, Qun-Ying Lei. Acetylation Control of Metabolic Enzymes in Cancer: an Updated Version. Acta Biochimica et Biophysica Sinica. 2014 Mar;46(3):204-13.

6. Xin Zhou, Shuyang Wang,Zhen Wang, Xu Feng，Peng Liu, Xian-Bo Lv, Fulong Li, Fa-Xing Yu, Yiping Sun, Haixin Yuan, Hongguang Zhu, Yue Xiong, Qun-Ying Lei, and Kun-Liang Guan. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May;125(5):2123-35.

7. Xian-Bo Lv, Chen-Ying Liu,Zhen Wang, Yi-ping Sun, Yue Xiong, Qun-Ying Lei, Kun-Liang Guan. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug;16(8):975-85.

8. Tingting Li, Mengxi Liu, Xu Feng,Zhen Wang, Indrani Das, Yanping Xu, Xin Zhou, Yiping Sun, Kun-Liang Guan, Yue Xiong and Qun-Ying Lei. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J Biol Chem. 2014 Feb 7;289(6):3775-85.

9. Xu Feng, Peng Liu, Xin Zhou, Meng-Tian Li, Fu-Long Li,Zhen Wang, Zhipeng Meng, Yi-Ping Sun, Ying Yu, Yue Xiong, Hai-Xin Yuan, Kun-Liang Guan. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 Sep 2; 291(36):18947-58.

五、联系方式（微软雅黑，四号；定格对齐；）

地址：河北省邯郸市经开区太极路19号河北工程大学，邮编：056001

E-mail:wangzhen@hebeu.edu.cn