王珍

一、履历

王珍，女，博士，副教授，硕士生导师。2012年毕业于河北大学获学士学位；2017年毕业于复旦大学获博士学位；2019年美国明尼苏达大学访问学者。河北工程大学医学院检验系主任、河北省高等学校青年拔尖人才、中国医药教育协会中医药慢病防治委员会常务委员、河北省糖尿病基础医学研究重点实验室外聘研究员、医学院肿瘤与代谢性疾病研究应用科研团队负责人。

二、研究方向

目前主要从事活性成分对代谢性相关疾病的作用及机制，基于体内体外实验，结合高通量测序和代谢组学，解析成分作用及干预策略。

三、主要科研成果

主持国家自然科学基金青年项目1项，省部级项目4项，市厅级项目3项，横向项目3项；参与国家自然科学基金、省级、市厅级项目5项，出版专著1部，授权发明专利1项，获河北省科学技术进步奖一等奖1项、中国煤炭教育协会哲学社会科学优秀成果奖三等奖1项。

四、代表性论文

1.Yan Yang, Jingjing Yan, Shuo Li, Mengru Liu, Ruimin Han, Yinping Wang, Zhen Wang*, Defeng Wang*. Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis. Endocrine. 2024 Apr;84(1):48-62.

2.Jia Ruikang#, Guo Xiaohui#, Liu Huiyun, Zhao Feiyue; Fan Zhibin, Wang Menglei, Sui Jianliang, Yin Binghua, Wang Zhihong, Wang Zhen. Analysis of Staged Features of Gastritis-Cancer Transformation and Identification of Potential Biomarkers in Gastric Cancer. J Inflamm Res. 2022 Dec 28;15:6857-6868.

3.Zhuang Li1#, Lu Meng1#, Qingyun Ma, Zhen Wang*, Youxing Zhao* and Duqiang Luo*.Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134. Front Microbiol. 2022 Sep 29;13:975579.

4.Li, Yanhui; Xiong, Yue; Wang, Zhen; Han, Jianjun; Shi, Sufang; He, Jinglan; Shen, Na; Wu,Wenjuan; Wang, Rui; Lv, Weiwei; Deng, Yajun; Liu, Weiguang ; FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway, CANCER CELL INTERNATIONAL, 2021, 21(1).

5. Zhen Wang, Peng Liu, Xin Zhou, Tianxiang Wang, Xu Feng, Yi-Ping Sun, Yue Xiong, Hai-Xin Yuan and Kun-Liang Guan. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Research. 2017 May 1;77(9):2413-2423.  

6. Zhen Wang, Li Sun, Shuang Liang, Zan-chao Liu , Zeng-yi Zhao , Jie Yang , Defeng Wang , Da-Qing Yang. GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCb-PKC and Rho/ROCK-LIMK-Cofilin pathway. Biochem Biophys Res Commun. 2019 Aug 27;516(3):976-982.

7. Hai-Xin Yuan, Zhen Wang, Fa-Xing Yu, Fulong Li, Ryan C. Russell, Jenna L. Jewell, Kun-Liang Guan. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes and Development. 2015 Nov 15; 29(22):2362-76.

8. Xin Zhou†, Zhen Wang†，Wei Huang, Qun-ying Lei. G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):10-5.

9. Wei Huang†, Zhen Wang†, Qun-Ying Lei. Acetylation Control of Metabolic Enzymes in Cancer: an Updated Version. Acta Biochimica et Biophysica Sinica. 2014 Mar;46(3):204-13.

10. Xin Zhou, Shuyang Wang, Zhen Wang, Xu Feng，Peng Liu, Xian-Bo Lv, Fulong Li, Fa-Xing Yu, Yiping Sun, Haixin Yuan, Hongguang Zhu, Yue Xiong, Qun-Ying Lei, and Kun-Liang Guan. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May;125(5):2123-35.

11. Xian-Bo Lv, Chen-Ying Liu, Zhen Wang, Yi-ping Sun, Yue Xiong, Qun-Ying Lei, Kun-Liang Guan. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug;16(8):975-85.

12. Tingting Li, Mengxi Liu, Xu Feng, Zhen Wang, Indrani Das, Yanping Xu, Xin Zhou, Yiping Sun, Kun-Liang Guan, Yue Xiong and Qun-Ying Lei. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J Biol Chem. 2014 Feb 7;289(6):3775-85.

13. Xu Feng, Peng Liu, Xin Zhou, Meng-Tian Li, Fu-Long Li, Zhen Wang, Zhipeng Meng, Yi-Ping Sun, Ying Yu, Yue Xiong, Hai-Xin Yuan, Kun-Liang Guan. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 Sep 2; 291(36):18947-58.

五、联系方式

地址：河北省邯郸市经开区太极路19号河北工程大学，邮编：056001

E-mail:wangzhen@hebeu.edu.cn